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In a very recent examine, we noted the identification and the characterization of a new atypical opioid receptor with exclusive negative regulatory properties toward opioid peptides.1 Our benefits confirmed that ACKR3/CXCR7, hitherto referred to as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can be a broad-spectrum scavenger fo